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结直肠癌组织RPN11与Ki67的表达及其临床病理学意义

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结直肠癌组织RPN11与Ki67的表达及其临床病理学意义
Expression of RPN11 and Ki67 in colorectal cancer and its clinicopathological significance
上传时间:2019/8/23 19:31:46    作者:王晓林,金玲玲,张瑶,曹仕琼|下载

王晓林1,金玲玲1,张瑶2*,曹仕琼1
(华中科技大学同济医学院附属梨园医院1消化内科,2内分泌科,武汉  430077)

Wang Xiaolin1, Jin Lingling1, Zhang Yao2*, Cao Shiqiong1
(1Department of Gastroenterology, 2Department of Endocrinology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China)
摘要:目的 观察去泛素化酶RPN11和增殖相关核标记物Ki67在结直肠癌组织中的表达,研究其与结直肠癌肿瘤细胞增殖的相关性及与结直肠癌临床病理特征的关系。方法 采用免疫组织化学SABC法检测56例结直癌组织及20例癌旁正常组织中的RPN11和Ki67表达,结合临床病理学资料进行统计分析。结果 免疫组织化学染色显示:RPN11及Ki67在结直肠癌组织的阳性表达率明显高于正常结直肠组织;RPN11和Ki67的表达均与肿瘤分化程度、TNM分期、转移有关,而与性别、年龄无明显相关; RPN11与Ki67的表达呈正相关。结论 RPN11和Ki67可能共同参与结直肠癌肿瘤细胞的增殖调控,并促进结直肠癌的发生发展以及浸润转移。
关键词:结直肠癌;去泛素化酶;26S蛋白酶体;RPN11;Ki67
Abstract:Objective To observe the expression of deubiquitinase RPN11 and proliferation-associated nuclear marker Ki67 in colorectal cancer tissues, and to study its correlation with the proliferation of colorectal cancer cells and clinicopathological features of colorectal cancer. Methods Immunohistochemistry (SABC) was used to detect the expression of RPN11 and Ki67 in 56 cases of colorectal cancer tissues and 20 cases of adjacent normal tissues, which was statistically analyzed with clinicopathological data. Results The results of immunohistochemistry showed that the positive expression rate of RPN11 and Ki67 in colorectal cancer tissues was significantly higher than that in adjacent normal colorectal tissues. The expression of RPN11 and Ki67 was correlated with tumor differentiation, TNM stage and metastasis, while was not significantly correlated with gender and age. Correlation analysis showed that RPN11 was positively correlated with Ki67 expression. Conclusion RPN11 and Ki67 may participate in the proliferation regulation of colorectal cancer cells and promote the development, invasion and metastasis of colorectal cancer.
Keywords: Colorectal cancer; deubiquitinase; 26S proteasome; RPN11; Ki67

〔中图分类号〕R365             〔文献标识码〕A             DOI:10.16705/ j. cnki. 1004-1850. 2019. 03. 009
 

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