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TMEM16A与p-p38在乳腺浸润性导管癌中的表达及其意义

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TMEM16A与p-p38在乳腺浸润性导管癌中的表达及其意义
Expression of TMEM16A and p-p38 in breast invasive ductal cancer and its significance
上传时间:2019/8/23 19:26:53    作者:沈恒石,韩艳春, 张骞,马莉,赵塞|下载

沈恒石1*,韩艳春2, 张骞2,马莉2,赵塞2
(1沈阳市第二中医医院病理科,沈阳 110101;2滨州医学院病理学教研室,烟台 264003)

Shen Hengshi1*, Han Yanchun 2, Zhang Qian2, Ma Li2, Zhao Sai2
(1Department of Pathology, Shenyang second hospital of traditional Chinese medicine , Shenyang 110101; 2Department of Pathology, Binzhou Medical University, Yantai 264003, China)
摘要:目的 探讨TMEM16A和磷酸化p38(p-p38)的相互关系及在乳腺浸润性导管癌组织中表达的临床意义。方法 应用免疫组织化学方法检测60对乳腺浸润性导管癌及相应癌旁组织中TMEM16A和p-p38蛋白的表达情况,对TMEM16A和p-p38表达与乳腺癌临床病理特征关系进行统计学分析,并分析TMEM16A和p-p38表达的相关性,探讨其表达与乳腺癌患者预后的关系。结果 乳腺浸润性导管癌组织中TMEM16A的表达阳性率明显高于相应癌旁组织中TMEM16A的表达阳性率。TMEM16A表达与乳腺癌患者组织学分级、淋巴结转移显著相关。乳腺浸润性导管癌组织中p-p38的表达阳性率为60%,而相应癌旁组织中未见明显p-p38的阳性表达。p-p38表达与乳腺癌患者TNM分期、淋巴结转移显著相关。乳腺浸润性导管癌组织中TMEM16A和p-p38的表达呈正相关关系。TMEM16A和p-p38高表达的乳腺浸润性导管癌患者术后无复发生存期低于低表达者的生存期。结论 TMEM16A与p-p38表达与乳腺浸润性导管癌恶性表型有关,TMEM16A可能通过激活p38促进乳腺浸润性导管癌的转移,TMEM16A和p-p38的表达可辅助用于乳腺浸润性导管癌的预后评估。
关键词:TMEM16A; p-p38;乳腺癌
Abstract:Objective To explore the relationship between TMEM16A and p-p38 and the clinical significance in breast invasive ductal cancer. Methods Immunohistochemical staining was used to detect the expression of TMEM16A and p-p38 proteins in 60 pairs of breast invasive ductal cancer tissues and corresponding cancer adjacent tissues. Statistical analysis was performed on the relationship between TMEM16A and p-p38 expression and clinicopathological features of breast cancer. The correlation between TMEM16A and p-p38 expression and the relationship between theirs expression and prognosis of breast cancer patients were also analyzed. Results The rate of positive expression of TMEM16A in breast invasive ductal cancer tissues was significantly higher than that in cancer adjacent tissues. TMEM16A expression was significantly positively associated with histological grade and lymph node metastasis in the breast cancer cases. The rate of positive expression of p-p38 in breast invasive ductal cancer tissues was 60%, while there was no obvious p-p38 expression in cancer adjacent tissues. P-p38 expression was significantly positively associated with TNM stage and lymph node metastasis in the breast cancer cases. TMEM16A expression was positively correlated with the expression of p-p38. The recurrence-free survival rate of patients with high expression of TMEM16A and p-p38 was lower than that of patients with low expression. Conclusion The expression of TMEM16A and p-p38 was correlated with malignant phenotype of breast invasive ductal cancer, and TMEM16A promotes its metastasis by activating p38. The expression of TMEM16A and p-p38 may be applied to prognostic estimate of breast invasive ductal cancer patients.
Keywords:TMEM16A; p-p38; breast cancer
〔中图分类号〕R735.2             〔文献标识码〕A             DOI:10.16705/ j. cnki. 1004-1850. 2019. 03. 010

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